Kripke S A, De Paula J A, Berman J M, Fox A D, Rombeau J L, Settle R G
Philadelphia Veterans Affairs Medical Center, Philadelphia.
Am J Clin Nutr. 1991 Apr;53(4):954-62. doi: 10.1093/ajcn/53.4.954.
To determine whether short-chain triglycerides (SCTs, 1:1 triacetin:tributyrin, wt:wt) enhance intestinal adaptation in short-bowel syndrome (SBS), male Sprague-Dawley rats underwent 60% distal small-bowel resection with cecectomy and received either a chemically defined diet (CD) or a CD containing 40% of nonprotein energy as either medium-chain triglycerides (MCTs) or SCTs. After 12 d the SCT group had significantly increased jejunal mucosal weight compared with the MCT and CD groups and had significantly increased segment weight and mucosal protein compared with the CD group. In the colon the SCT group had significantly increased segment and mucosal weights and mucosal protein and DNA compared with both the MCT and CD groups. Body-weight change and measurements of serum ketones, albumin, glucose, and triglycerides revealed no significant differences among groups. SCTs improved jejunal and colonic adaptive growth and maintained comparable nutritional status in SBS when compared with CD alone or CD with MCTs.
为了确定短链甘油三酯（SCTs，三醋精与三丁酸甘油酯按1:1，重量比）是否能增强短肠综合征（SBS）中的肠道适应性，对雄性Sprague-Dawley大鼠进行了60%远端小肠切除并切除盲肠，然后给予化学限定饮食（CD）或含有40%非蛋白能量的CD，非蛋白能量来源为中链甘油三酯（MCTs）或SCTs。12天后，与MCT组和CD组相比，SCT组空肠黏膜重量显著增加，与CD组相比，SCT组节段重量和黏膜蛋白显著增加。在结肠，与MCT组和CD组相比，SCT组节段和黏膜重量以及黏膜蛋白和DNA均显著增加。体重变化以及血清酮体、白蛋白、葡萄糖和甘油三酯的测量结果显示，各组之间无显著差异。与单独使用CD或CD加MCTs相比，SCTs改善了SBS中空肠和结肠的适应性生长，并维持了相当的营养状况。
