Juhn Young J, Kita Hirohito, Lee Linda A, Swanson Rebecca J, Smith Ryan, Bagniewski Stephanie M, Weaver Amy L, Pankratz V Shane, Jacobson Robert M, Poland Gregory A
Division of Pediatric and Adolescent Medicine, Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA.
Ann Allergy Asthma Immunol. 2006 Oct;97(4):469-76. doi: 10.1016/S1081-1206(10)60937-4.
Asthmatic patients have a TH2-predominant milieu that is associated with humoral immunity. However, little is known about whether humoral immune responses to viral antigens differ between asthmatic and nonasthmatic children.
To determine whether humoral immune response differs in asthmatic patients vs nonasthmatic patients.
Measles virus specific IgG antibody levels were determined for the Rochester Family Measles Study cohort (n = 876), a convenience sample of healthy children 5 to 12 years of age in Rochester, MN. We conducted comprehensive medical record reviews of 838 children who were eligible for this study. We determined the child's asthma status at the time of determination of antibody levels by applying predetermined criteria for asthma. Comparisons were made using the 2-sample t test or chi2 test.
Of the 838 children, 156 (18.6%) had asthma at the time of the determination of antibody levels and were not taking systemic steroids within 14 days of specimen collection. Among those with a nonequivocal antibody reading, the seropositive response rates were similar in asthmatic patients and nonasthmatic patients (89.7% vs 90.3%, respectively; P = .83). However, the equivocal response rates were slightly higher among asthmatic patients than nonasthmatic patients (6.4% vs 4.7%, respectively).
Asthmatic children seem to have similar humoral immune responses to measles vaccine as those without asthma. Although the findings reassure health care practitioners, whether this finding is generalizable to other vaccines and whether asthmatic patients with low antibody levels have normal cell-mediated immunity need to be elucidated in future studies.
哮喘患者具有以TH2为主导的环境，这与体液免疫相关。然而，对于哮喘儿童和非哮喘儿童对病毒抗原的体液免疫反应是否存在差异，人们了解甚少。
确定哮喘患者与非哮喘患者的体液免疫反应是否存在差异。
对明尼苏达州罗切斯特市5至12岁健康儿童的便利样本罗切斯特家庭麻疹研究队列（n = 876）测定麻疹病毒特异性IgG抗体水平。我们对838名符合本研究条件的儿童进行了全面的病历审查。我们通过应用预定的哮喘标准来确定抗体水平测定时儿童的哮喘状态。使用两样本t检验或卡方检验进行比较。
在838名儿童中，156名（18.6%）在抗体水平测定时患有哮喘，且在标本采集后14天内未服用全身性激素。在抗体读数明确的儿童中，哮喘患者和非哮喘患者的血清阳性反应率相似（分别为89.7%和90.3%；P = 0.83）。然而，哮喘患者的可疑反应率略高于非哮喘患者（分别为6.4%和4.7%）。
哮喘儿童对麻疹疫苗的体液免疫反应似乎与非哮喘儿童相似。尽管这些发现让医护人员放心，但这一发现是否适用于其他疫苗以及抗体水平低的哮喘患者细胞介导免疫是否正常，需要在未来的研究中阐明。
