Gazi Irene F, Filippatos Theodosios D, Tsimihodimos Vasilis, Saougos Vasilios G, Liberopoulos Evangelos N, Mikhailidis Dimitri P, Tselepis Alexandros D, Elisaf Moses
Department of Internal Medicine, Medical School, University of Ioannina, Ioannina, Greece.
Lipids. 2006 Jul;41(7):647-54. doi: 10.1007/s11745-006-5015-8.
The hypertriglyceridemic waist (HTGW) phenotype (hypertriglyceridemia and increased waist circumference) has been proposed as an inexpensive tool to monitor individuals with the atherogenic metabolic triad, hyperinsulinemia, hyperapobetalipoproteinemia, and increased levels of small, dense LDL (sdLDL) particles. We assessed the association of the HTGW phenotype with the metabolic syndrome (MetSyn) and the atherogenic metabolic triad in inhabitants (n = 260) of northwestern Greece attending the Outpatient Lipid Clinic of the University Hospital of Ioannina. The LDL subfractions were assessed using the Lipoprint LDL System. HTGW (+) individuals had a more adverse lipid and lipoprotein profile compared with HTGW (-) individuals. Moreover, HTGW (+) subjects had elevated levels of sdLDL-C, as well as decreased mean and peak LDL particle size compared with HTGW (-) subjects. To our knowledge, this is the first report documenting the sdLDL-C abnormality in HTGW (+) subjects. Among men (n = 105), 52.3% of the MetSyn (+) individuals and 66.7% of the HTGW (+) individuals had the metabolic triad. Among women (n = 155), the corresponding percentages were 42.3% and 50.0%. Only 22.2% and 10.6% of the MetSyn (-) subjects (men and women, respectively) and 19.6% and 15.2% of the HTGW (-) subjects (men and women, respectively) had the atherogenic metabolic triad. In conclusion, the HTGW (+) phenotype is associated with a hostile lipid profile that includes higher levels of sdLDL-C and decreased LDL particle size. The HTGW phenotype, compared with the MetSyn criteria, can provide an easy and inexpensive tool to monitor patients characterized by an adverse lipid and lipoprotein profile.
高甘油三酯腰围（HTGW）表型（高甘油三酯血症和腰围增加）已被提议作为一种经济实惠的工具，用于监测患有致动脉粥样硬化代谢三联征、高胰岛素血症、高载脂蛋白血症以及小而密低密度脂蛋白（sdLDL）颗粒水平升高的个体。我们评估了希腊西北部约阿尼纳大学医院门诊脂质诊所的居民（n = 260）中HTGW表型与代谢综合征（MetSyn）和致动脉粥样硬化代谢三联征之间的关联。使用Lipoprint LDL系统评估低密度脂蛋白亚组分。与HTGW（-）个体相比，HTGW（+）个体具有更不利的脂质和脂蛋白谱。此外，与HTGW（-）受试者相比，HTGW（+）受试者的sdLDL-C水平升高，同时平均和峰值低密度脂蛋白颗粒大小减小。据我们所知，这是第一份记录HTGW（+）受试者中sdLDL-C异常的报告。在男性（n = 105）中,52.3%的MetSyn（+）个体和66.7%的HTGW（+）个体患有代谢三联征。在女性（n = 155）中，相应的百分比分别为42.3%和50.0%。只有22.2%和10.6%的MetSyn（-）受试者（分别为男性和女性）以及19.6%和15.2%的HTGW（-）受试者（分别为男性和女性）患有致动脉粥样硬化代谢三联征。总之，HTGW（+）表型与不良脂质谱相关，包括较高水平的sdLDL-C和减小的低密度脂蛋白颗粒大小。与MetSyn标准相比，HTGW表型可以提供一种简单且经济的工具，用于监测具有不良脂质和脂蛋白谱特征的患者。
