Department of Biomedical and Clinical Technology, Durban University of Technology, South Africa.
Department of Cardiology, University of KwaZulu-Natal, South Africa.
Diabetes Metab Syndr. 2022 Jun;16(6):102524. doi: 10.1016/j.dsx.2022.102524. Epub 2022 May 27.
The combination of high triglycerides and increased waist circumference (HTGW) has not been examined as a predictor of cardiometabolic abnormalities or the metabolic syndrome (MetS) in high-risk Asian populations. This study examines the so-called hypertriglyceridemia waist (HTGW) phenotype, (high serum triglycerides [Tg]) and increased waist circumference (WC) as a predictor of cardiometabolic abnormalities in a high-risk Asian population.
Data from the Phoenix Lifestyle Project, a cross-sectional study of 1349 South Asian Indians (15-65 years; 379 men; 970 women) in Durban, KwaZulu-Natal, were reclassified into different waist and Tg phenotypes using the demographic, anthropometric, and biochemical parameters. The HTGW phenotype was defined as WC ≥ 90 cm for men; ≥80 cm for women & TG ≥ 1.7 mmol/L. The MetS was determined using the harmonised criteria. Stepwise logistic regression was used to determine the strength of each phenotype as a predictor of the MetS.
The HTGW phenotype was recorded in 35.4% of participants, predominantly women (36.1%) and 8.2% smokers. Metabolic derangements and cardiovascular risk factors increased significantly in those with HTGW phenotype. After adjustment, multivariate logistic regression showed that the association between elevated total serum cholesterol, LDL, lowered HDL, diabetes and hypertension with HTGW persisted. The odds for participants with the HTGW phenotype developing the MetS was 19.7 (95% CI 13.9; 27.9). The degree of concordance between the HTGW was highest with the IDF and harmonised criteria for MetS.
The HTGW phenotype was associated with a significantly higher risk of developing additional lipid derangements, hypertension, diabetes and the MetS.
高甘油三酯和腰围增加（HTGW）的组合尚未被研究作为高风险亚洲人群中心血管代谢异常或代谢综合征（MetS）的预测因子。本研究旨在检查所谓的高甘油三酯血症腰围（HTGW）表型（高血清甘油三酯[TG]）和腰围增加（WC）作为高风险亚洲人群中心血管代谢异常的预测因子。
本研究的数据来自凤凰生活方式项目，这是一项横断面研究，共纳入了来自夸祖鲁-纳塔尔省德班的 1349 名南亚印度人（年龄 15-65 岁；男性 379 名，女性 970 名），根据人口统计学、人体测量学和生化参数将其重新分类为不同的腰围和 TG 表型。HTGW 表型定义为男性 WC≥90cm；女性 WC≥80cm 和 TG≥1.7mmol/L。MetS 采用协调标准确定。逐步逻辑回归用于确定每种表型作为 MetS 预测因子的强度。
在 35.4%的参与者中记录到 HTGW 表型，主要为女性（36.1%）和 8.2%的吸烟者。在 HTGW 表型的参与者中，代谢紊乱和心血管危险因素显著增加。调整后，多元逻辑回归显示，总血清胆固醇、LDL 升高、HDL 降低、糖尿病和高血压与 HTGW 之间的相关性仍然存在。患有 HTGW 表型的参与者发生 MetS 的几率为 19.7（95%CI 13.9；27.9）。HTGW 与 IDF 和 MetS 协调标准的一致性程度最高。
HTGW 表型与发生其他脂质异常、高血压、糖尿病和 MetS 的风险显著增加相关。
