Department of Biomedical Physiology and Kinesiology, Simon Fraser University, 2600-515 W Hastings Street, Vancouver V6B 5K3, BC, Canada.
Lipids Health Dis. 2014 Feb 23;13:38. doi: 10.1186/1476-511X-13-38.
"Hypertriglyceridemic waist" (HTGW) phenotype, an inexpensive early screening tool for detection of individuals at risk for type 2 diabetes and cardiovascular disease was found to be associated with subclinical atherosclerosis in various patient populations such as those with diabetes mellitus, chronic kidney disease, and those infected with human immunodeficiency virus. However, less is known regarding an association between HTGW and subclinical atherosclerosis in the apparently healthy, multiethnic population. Therefore, the aim of the study was to explore the association between HTGW and sub-clinical atherosclerosis in an apparently healthy, multiethnic population; and to investigate whether the effect of HTGW on sub-clinical atherosclerosis persists over and above the traditional atherosclerosis risk factors.
We studied 809 individuals of Aboriginal, Chinese, European and South Asian origin who were assessed for indices of sub-clinical atherosclerosis (intima-media thickness (IMT), total area and presence of carotid plaques), socio-demographic and lifestyle characteristics, anthropometrics, lipids, glucose, blood pressure, and family history of cardiovascular disease.
We found that, compared to individuals without HTGW and after adjusting for age, ethnicity, smoking, and physical activity; men and women with HTGW had a significantly higher: IMT (men: B (95%CI = 0.084 (0.037, 1.133), p < 0.001; women: B (95%CI) = 0.041 (0.006, 0.077), p = 0.020); and total area (men: B (95%CI = 0.202 (0.058, 0.366), p = 0.005; women: B (95%CI) = 0.115 (0.006, 0.235), p = 0.037). The association between HTGW waist and presence of plaques was significant for men (OR (95%CI) = 1.904 (1.040, 3.486), p = 0.037 vs. men without HTGW), but not for women (p = 0.284). Once analyses were adjusted for additional, traditional risk factors for atherosclerosis, the effect of HTGW on sub-clinical atherosclerosis was no longer significant.
In conclusion, HTGW may serve as an early marker of subclinical atherosclerosis in men and women, irrespective of ethnicity. However, once individuals are assessed for all traditional risk factors for atherosclerosis, the additional assessment for HTGW is not warranted.
“高甘油三酯腰围”（HTGW）表型是一种廉价的早期筛查工具，可用于检测 2 型糖尿病和心血管疾病风险增加的个体，已在糖尿病、慢性肾脏病和感染人类免疫缺陷病毒的患者等多种患者群体中发现与亚临床动脉粥样硬化有关。然而，对于 HTGW 与亚临床动脉粥样硬化在看似健康的多民族人群中的关系，人们知之甚少。因此，本研究的目的是探讨 HTGW 与亚临床动脉粥样硬化在看似健康的多民族人群中的关系；并探讨 HTGW 对亚临床动脉粥样硬化的影响是否超过传统的动脉粥样硬化危险因素。
我们研究了 809 名澳大利亚原住民、中国、欧洲和南亚裔个体，评估了亚临床动脉粥样硬化的指标（内-中膜厚度（IMT）、总面积和颈动脉斑块的存在）、社会人口统计学和生活方式特征、人体测量学、血脂、血糖、血压和心血管疾病家族史。
我们发现，与没有 HTGW 的个体相比，且在调整年龄、种族、吸烟和体力活动后，有 HTGW 的男性和女性的 IMT（男性：B（95%CI=0.084（0.037,1.133），p<0.001；女性：B（95%CI）=0.041（0.006,0.077），p=0.020）和总面积（男性：B（95%CI）=0.202（0.058,0.366），p=0.005；女性：B（95%CI）=0.115（0.006,0.235），p=0.037）显著更高。HTGW 腰围与斑块存在的相关性在男性中具有统计学意义（OR（95%CI）=1.904（1.040,3.486），p=0.037 与没有 HTGW 的男性相比），但在女性中无统计学意义（p=0.284）。一旦分析调整了动脉粥样硬化的其他传统危险因素，HTGW 对亚临床动脉粥样硬化的影响就不再显著。
总之，HTGW 可能是男性和女性亚临床动脉粥样硬化的早期标志物，与种族无关。然而，一旦对动脉粥样硬化的所有传统危险因素进行评估，就不需要对 HTGW 进行额外评估。
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