急性烟雾诱导的内皮功能障碍在吸烟者中比在非吸烟者中持续时间更长。
Acute smoke-induced endothelial dysfunction is more prolonged in smokers than in non-smokers.
作者信息
Karatzi Kalliopi, Papamichael Christos, Karatzis Emmanouil, Papaioannou Theodore G, Stamatelopoulos Kimon, Zakopoulos Nikolaos A, Zampelas Antonis, Lekakis John
出版信息
Int J Cardiol. 2007 Sep 3;120(3):404-6. doi: 10.1016/j.ijcard.2006.07.200. Epub 2006 Oct 27.
BACKGROUND
The aim of the study was to compare acute endothelial dysfunction caused by smoking one cigarette between smokers and non-smokers.
METHODS
Thirty volunteers, 15 smokers and 15 non-smokers, were asked to smoke the same type of cigarette and endothelial function was assessed by FMD (flow mediated dilatation) at fast, 30, 60 and 90 min post-smoking.
RESULTS
Overall response of FMD after smoking was significantly different between smokers and non-smokers (p=0.011). Endothelial dysfunction after smoking remained significant for 1-h in smokers (p=0.002), but only for 30 min in non-smokers (p=<0.001). FMD 1-h after smoking was significantly higher in non-smokers than in smokers (p=0.002).
CONCLUSIONS
Smokers seem to have sustained and more intensive unfavourable effects in endothelial function than non-smokers after smoking one cigarette. It is possible that long-term smoking diminishes the capacity of endothelium to counterbalance external factors that cause endothelial dysfunction.
背景
本研究的目的是比较吸烟者和非吸烟者吸一支烟后引起的急性内皮功能障碍。
方法
30名志愿者，15名吸烟者和15名非吸烟者，被要求吸同一类型的香烟，并在吸烟后即刻、30分钟、60分钟和90分钟通过血流介导的血管舒张（FMD）评估内皮功能。
结果
吸烟者和非吸烟者吸烟后FMD的总体反应有显著差异（p = 0.011）。吸烟后内皮功能障碍在吸烟者中持续1小时仍显著（p = 0.002），但在非吸烟者中仅持续30分钟（p < 0.001）。吸烟后1小时非吸烟者的FMD显著高于吸烟者（p = 0.002）。
结论
吸烟者吸一支烟后在内皮功能方面似乎比非吸烟者有更持久、更强烈的不利影响。长期吸烟可能会降低内皮平衡引起内皮功能障碍的外部因素的能力。
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