上皮癌异位表达人绒毛膜促性腺激素β亚基：恶性行为、转移及对肿瘤细胞凋亡的抑制作用

Ectopic hCGbeta expression by epithelial cancer: malignant behaviour, metastasis and inhibition of tumor cell apoptosis.

作者信息

Iles R K

机构信息

Department of Biomedical Sciences, Institute of Social and Health Research, Middlesex University, Queensway, Enfield Middlesex EN3 4SA, UK.

出版信息

Mol Cell Endocrinol. 2007 Jan 2;260-262:264-70. doi: 10.1016/j.mce.2006.02.019. Epub 2006 Oct 27.

DOI:10.1016/j.mce.2006.02.019

PMID:17069968

Abstract

Ectopic expression of the beta-subunit of human chorionic gonadotropin (hCG) is now a recognized phenomenon in 20-40% of all common epithelial carcinoma arising from mucosal epithelia such as bladder, cervix, lung and naso-pharynx. Recent studies have shown that it acts as an autocrine growth factor by inhibiting apoptosis. Structural homology and in vitro studies suggest that it may achieve this by inhibition of the transforming growth factor beta (TGFbeta) receptor complex. Such a molecular mechanism would go some way to explaining ectopic hCGbeta's association with poor prognosis and tumors that will rapidly progress to metastasis.

摘要

人绒毛膜促性腺激素（hCG）β亚基的异位表达目前是一种公认的现象，在所有源自黏膜上皮（如膀胱、子宫颈、肺和鼻咽）的常见上皮癌中，有20% - 40%会出现这种情况。最近的研究表明，它通过抑制细胞凋亡来充当自分泌生长因子。结构同源性和体外研究表明，它可能通过抑制转化生长因子β（TGFβ）受体复合物来实现这一点。这样的分子机制将在一定程度上解释异位hCGβ与预后不良以及将迅速发展为转移的肿瘤之间的关联。