高糖基化 hCG、hCGβ 和高糖基化 hCGβ：可互换的癌症促进剂。
Hyperglycosylated hCG, hCGβ and Hyperglycosylated hCGβ: interchangeable cancer promoters.
机构信息
USA hCG Reference Service, Department of Obstetrics and Gynecology, Health Sciences Center MSC10-5580, 1 University of New Mexico, Albuquerque, NM 87104, USA.
出版信息
Mol Cell Endocrinol. 2012 Feb 26;349(2):232-8. doi: 10.1016/j.mce.2011.10.029. Epub 2011 Nov 12.
INTRODUCTION
Several groups are researching cancers, and showing that hCGβ is a promoter of cancer growth and malignancy. Recent research shows that some hCGβ is present as Hyperglycosylated hCGβ. Other groups studied Hyperglycosylated hCG as a promoter of choriocarcinoma and germ cell malignancies. The question therefore arises, are Hyperglycosylated hCG, hCGβ and Hyperglycosylated hCGβ interrelated or interchangable promoters of cancer?
METHODS
The actions of Hyperglycosylated hCGβ, hCGβ and Hyperglycosylated hCG are investigated in 7 cell lines, Jar and JEG-3 choriocarcinoma cell lines, NTERA germ cell cancer line, SCaBER and T24 bladder epithelial carcinoma lines, KLE and Hec-1-a endometrial adenocarcinoma and epithelial carcinoma cell lines. Actions of promoters on cell growth are investigated.
RESULTS
The actions of Hyperglycosylated hCG, hCGβ and Hyperglycosylated hCGβ appear to be interchangeable in all cell lines investigated.
DISCUSSION
All hCG-related cancer promoters seem interrelated, working through a similar mechanism, antagonism of apoptosis through know receptors such as TGFβ receptors in all cancers studied.
简介
有几个研究小组正在研究癌症，并表明 hCGβ 是促进癌症生长和恶性转化的因素。最近的研究表明，一些 hCGβ 以高糖基化 hCGβ 的形式存在。其他研究组研究了高糖基化 hCG 作为绒毛膜癌和生殖细胞恶性肿瘤的促进剂。因此，问题出现了，高糖基化 hCG、hCGβ 和高糖基化 hCGβ 是否是相互关联或可互换的癌症促进剂？
方法
在 7 种细胞系中研究了高糖基化 hCGβ、hCGβ 和高糖基化 hCG 的作用，这些细胞系包括 Jar 和 JEG-3 绒癌细胞系、NTERA 生殖细胞癌系、SCaBER 和 T24 膀胱上皮癌细胞系、KLE 和 Hec-1-a 子宫内膜腺癌和上皮癌细胞系。研究了启动子对细胞生长的作用。
结果
在所有研究的细胞系中，高糖基化 hCG、hCGβ 和高糖基化 hCGβ 的作用似乎是可互换的。
讨论
所有与 hCG 相关的癌症促进剂似乎都相互关联，通过类似的机制起作用，通过所有研究癌症中的已知受体（如 TGFβ 受体）拮抗细胞凋亡。
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