Shimada Keiji, Nakamura Mitsutoshi, Ishida Eiwa, Konishi Noboru
Department of Pathology, Nara Medical University School of Medicine, Nara, Japan.
Urology. 2006 Oct;68(4):891.e7-10. doi: 10.1016/j.urology.2006.05.029.
Plasmacytoid urothelial carcinoma is a rare malignant neoplasm in the urinary bladder. A 46-year-old man presented with gross hematuria and increased serum concentrations of both carbohydrate antigen (CA) 19-9 and beta-human chorionic gonadotropin (beta-hCG). The tumor was composed of conventional urothelial carcinoma and plasmacytoid variant, both positive for epithelial markers. In addition, plasmacytoid tumor cells were positive for an accepted marker of plasma cell origin, CD138. CA19-9 was mainly expressed in conventional urothelial carcinoma cells, and beta-hCG was mainly produced by plasmacytoid tumor cells. This is the first report, to our knowledge, indicating beta-hCG can be produced by plasmacytoid bladder cancer cells lacking trophoblastic features.
浆细胞样尿路上皮癌是膀胱中一种罕见的恶性肿瘤。一名46岁男性出现肉眼血尿，血清中糖类抗原（CA）19-9和β-人绒毛膜促性腺激素（β-hCG）浓度均升高。肿瘤由传统尿路上皮癌和浆细胞样变体组成，两者上皮标志物均呈阳性。此外，浆细胞样肿瘤细胞对于公认的浆细胞起源标志物CD138呈阳性。CA19-9主要表达于传统尿路上皮癌细胞，β-hCG主要由浆细胞样肿瘤细胞产生。据我们所知，这是第一份表明缺乏滋养层特征的浆细胞样膀胱癌细胞可产生β-hCG的报告。
