McLoone Eibhlin M, O'Keefe Michael, McLoone Sean F, Lanigan Bernadette M
Department of Ophthalmology, Children's University Hospital, Dublin, Ireland.
J AAPOS. 2006 Oct;10(5):454-9. doi: 10.1016/j.jaapos.2006.05.005.
To assess the long-term refractive and biometric outcomes of diode laser-treated eyes in threshold retinopathy of prematurity (ROP).
Cycloplegic autorefraction and biometry (Zeiss IOLMaster) were performed, at a mean follow-up of 11 years, on 16 laser-treated eyes with threshold ROP and 9 comparison eyes with subthreshold untreated ROP.
The laser-treated eyes had a mean spherical equivalent of -2.33 D with a mean astigmatic error of 1.38 D. The comparison eyes had a mean spherical equivalent of +1.07 D with a mean astigmatic error of 0.42 D. This trend toward increased myopia in treated eyes did not achieve statistical significance (p=0.08). The myopia in the laser group appeared to be slowly progressive in nature when compared with earlier refractive data for these patients. The laser-treated eyes had reduced anterior chamber depth (ACD) compared with the subthreshold eyes (p=0.02). When physiologic accommodation was inhibited by cycloplegic drops, the anterior chamber deepened by 0.13 mm in the laser-treated eyes and by 0.06 mm in the comparison eyes. This effect of accommodation on ACD did not differ significantly between the two groups (p=0.23). The laser-treated eyes and the comparison eyes did not differ significantly in terms of axial length, corneal power, corneal diameter, or lens power. However, both groups had steeper corneas, shallower anterior chambers, and shorter axial lengths when compared with historical full-term controls.
Myopia in premature infants requiring laser treatment for ROP is associated with a shallowing of the anterior chamber and a steepening of the cornea. Physiological accommodation is not impaired by laser therapy or by severe ROP.
评估二极管激光治疗阈值期早产儿视网膜病变（ROP）患儿眼睛的长期屈光和生物测量结果。
对16只接受激光治疗的阈值期ROP患儿眼睛和9只未治疗的亚阈值期ROP患儿对照眼睛进行了睫状肌麻痹验光和生物测量（蔡司IOLMaster），平均随访时间为11年。
接受激光治疗的眼睛平均等效球镜度为-2.33 D，平均散光误差为1.38 D。对照眼睛平均等效球镜度为+1.07 D，平均散光误差为0.42 D。治疗眼近视增加的这种趋势未达到统计学显著性（p = 0.08）。与这些患者早期的屈光数据相比，激光治疗组的近视似乎呈缓慢进展。与亚阈值期眼睛相比，接受激光治疗的眼睛前房深度（ACD）减小（p = 0.02）。当用睫状肌麻痹滴眼液抑制生理性调节时，接受激光治疗的眼睛前房加深0.13 mm，对照眼睛加深0.06 mm。两组之间调节对ACD的这种影响无显著差异（p = 0.23）。接受激光治疗的眼睛和对照眼睛在眼轴长度、角膜屈光力、角膜直径或晶状体屈光力方面无显著差异。然而，与足月正常对照的历史数据相比，两组的角膜均更陡峭，前房更浅，眼轴长度更短。
需要激光治疗ROP的早产儿近视与前房变浅和角膜变陡有关。激光治疗或严重ROP不会损害生理性调节。
