Farvardin Majid, Kalantari Zahra, Talebnejad Mohammadreza, Alamolhoda Marzieh, Norouzpour Amir
Department of Ophthalmology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Poostchi Ophthalmology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
J Ophthalmic Vis Res. 2022 Aug 15;17(3):384-389. doi: 10.18502/jovr.v17i3.11576. eCollection 2022 Jul-Sep.
In this case-control study, we measured visual acuity, objective refraction, ocular biometric parameters, and strabismus in premature cases classified according to the following categories: argon laser-treated retinopathy of prematurity (ROP), untreated spontaneously regressed ROP, no ROP, and full-term controls.
Cases with a history of prematurity at six years of age were categorized into the following groups: patients with a history of treated type 1 ROP using argon laser (group I), untreated spontaneously regressed ROP (group II), and no history of ROP (group III). Group IV included age-matched healthy full-term controls. Funduscopy was performed for all the cases and the control group.
In total, 24 eyes of 12 laser-treated ROP cases, 186 eyes of 93 spontaneously regressed ROP patients, 74 eyes of 37 premature cases with no history of ROP, and 286 eyes of 143 controls were included in the study. The mean spherical equivalent in the treated cases was not significantly different from that in the untreated cases and patients in group III. However, the average cylindrical power was significantly different among the groups ( 0.004). Furthermore, anisometropia ( 1.5 diopters) was diagnosed with a higher rate in the treated cases ( = 0.03). The corneal curvature of the laser-treated eyes was significantly steeper and the axial length was significantly shorter than those in the other groups ( 0.002 and 0.001, respectively, for multivariate analysis). Strabismus was found in three treated patients (25%). Additionally, there were three treated eyes (12.5%) diagnosed with macular dragging.
Premature cases including those who had a history of argon laser-treated ROP and those with untreated spontaneously regressed ROP showed acceptable long-term visual and refractive outcomes along with a fairly low rate of ocular disorders.
在这项病例对照研究中，我们对根据以下类别分类的早产儿进行了视力、客观验光、眼部生物测量参数和斜视测量：氩激光治疗的早产儿视网膜病变（ROP）、未经治疗自行消退的ROP、无ROP以及足月儿对照。
将六岁时有早产史的病例分为以下几组：使用氩激光治疗1型ROP的患者（第一组）、未经治疗自行消退的ROP患者（第二组）以及无ROP病史的患者（第三组）。第四组包括年龄匹配的健康足月儿对照。对所有病例和对照组进行了眼底检查。
该研究共纳入12例接受激光治疗ROP病例中的24只眼、93例自行消退ROP患者中的186只眼、37例无ROP病史的早产儿中的74只眼以及143例对照中的286只眼。治疗组病例的平均球镜等效度与未治疗组病例及第三组患者相比无显著差异。然而，各组之间的平均柱镜度数有显著差异（P = 0.004）。此外，治疗组病例中诊断出屈光参差（≥1.5屈光度）的比例更高（P = 0.03）。与其他组相比（多因素分析中分别为P = 0.002和P = 0.001），接受激光治疗的眼睛角膜曲率明显更陡，眼轴长度明显更短。在3例接受治疗的患者中发现了斜视（25%）。此外，有3只接受治疗的眼睛（12.5%）被诊断为黄斑牵拉。
包括有氩激光治疗ROP病史的早产儿以及未经治疗自行消退ROP的早产儿在内，其长期视力和屈光结果尚可，眼部疾病发生率相当低。
