Mongkolrattanothai Kanokporn, Peev Milen, Wheat L Joseph, Marcinak John
Section of Pediatric Infectious Diseases, Department of Pediatrics, University of Chicago, Chicago, IL 61637, USA.
Pediatr Infect Dis J. 2006 Nov;25(11):1076-8. doi: 10.1097/01.inf.0000241144.89426.2a.
Blastomycosis is an uncommonly recognized disease in pediatric patients. We describe 4 cases of pediatric blastomycosis that presented to our children's hospital, 2 with isolated pulmonary blastomycosis and 2 with disseminated blastomycosis. Because of variable clinical presentations and morbidity if treatment is delayed, physicians must maintain a high index of suspicion and obtain appropriate diagnostic tests promptly. For the first time, we report the effect of therapy on Blastomyces antigen clearance. In our experience, the urine antigen detection for B. dermatitidis is useful for diagnosis and follow up during therapy.
芽生菌病在儿科患者中是一种较少被认识的疾病。我们描述了4例在我们儿童医院就诊的儿童芽生菌病病例，2例为孤立性肺芽生菌病，2例为播散性芽生菌病。由于临床表现多样且治疗延迟会导致发病，医生必须保持高度的怀疑指数并及时进行适当的诊断测试。我们首次报告了治疗对芽生菌抗原清除的影响。根据我们的经验，皮炎芽生菌的尿液抗原检测对诊断和治疗期间的随访很有用。
