临床微生物学实验室实用指南：双相真菌感染的抗体和抗原检测方法
Practical Guidance for Clinical Microbiology Laboratories: Antibody and antigen detection methods for dimorphic fungal infections.
作者信息
Theel Elitza S, Kus Julianne V, Grys Thomas E, Ampel Neil M, Schwartz Ilan S, Zhang Sean X
机构信息
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
Public Health Ontario, Toronto, Ontario, Canada.
出版信息
Clin Microbiol Rev. 2025 Jun 12;38(2):e0000520. doi: 10.1128/cmr.00005-20. Epub 2025 May 21.
SUMMARYAntibody and antigen detection assays continue to play a significant role in the diagnosis of dimorphic fungal pathogens, including complex, , species, species species, and . The performance characteristics of serologic and antigen detection assays for these pathogens are variable, however, influenced by multiple factors, including sample type, disease presentation, patient immunostatus, and timing of specimen collection relative to symptom onset. As a result, there is a need for a centralized document summarizing the accuracy of currently available antibody and antigen detection assays for each of these agents, including discussion of individual assay nuances and caveats that should be considered by clinicians and laboratorians alike. In addition, this review provides expert recommendations for the utilization and interpretation of serologic and antigen detection assays for these dimorphic pathogens.
摘要
抗体和抗原检测试验在双相真菌病原体的诊断中继续发挥重要作用，这些病原体包括复杂的、、种、种和种。然而，针对这些病原体的血清学和抗原检测试验的性能特征各不相同，受到多种因素的影响，包括样本类型、疾病表现、患者免疫状态以及标本采集时间与症状出现时间的关系。因此，需要一份集中的文件，总结目前针对每种此类病原体的可用抗体和抗原检测试验的准确性，包括对临床医生和实验室工作人员都应考虑的各个试验细微差别和注意事项的讨论。此外，本综述还为这些双相病原体的血清学和抗原检测试验的使用和解读提供了专家建议。
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