Bendon R W
Department of Pathology and Laboratory Medicine, University of Cincinnati, OH 45267-0529.
Ann Clin Lab Sci. 1991 Jan-Feb;21(1):36-9.
Fetal serum markers, such as alpha fetoprotein (AFP), must traverse one of two very different pathways to reach maternal serum, either from fetus to amnion fluid, membranes and decidua or from fetal to maternal circulation through the placental villi. Alpha fetoprotein usually enters the amnion fluid through body wall defects uncovered by skin or through urine. Placental AFP leakage may be from villous hemorrhage or injury. These observations from anatomic pathology suggest that biochemical markers may exist to identify the source of elevated maternal serum AFP.
胎儿血清标志物，如甲胎蛋白（AFP），必须通过两种截然不同的途径之一才能进入母体血清，要么从胎儿进入羊水、胎膜和蜕膜，要么通过胎盘绒毛从胎儿循环进入母体循环。甲胎蛋白通常通过未被皮肤覆盖的体壁缺损或通过尿液进入羊水。胎盘甲胎蛋白渗漏可能源于绒毛出血或损伤。这些解剖病理学观察结果表明，可能存在生化标志物来识别母体血清甲胎蛋白升高的来源。
