Torimura T, Ueno T, Inuzuka S, Tanaka M, Abe H, Tanikawa K
Second Department of Medicine, Kurume University School of Medicine, Japan.
Arch Pathol Lab Med. 1991 Apr;115(4):365-71.
In 14 cases of hepatocellular carcinoma with capsule, we studied the mechanism of capsule formation by the immunoperoxidase technique using antibodies to types I, III, and IV collagen, antilaminin antibody, and anti-prolyl hydroxylase antibody. Marked round cell infiltration was observed in the noncancerous side of the capsule and around compressed hepatocytes near the capsule. Thin capsules were composed primarily of type III collagen produced by an increased number of fibroblasts, transitional Ito cells, and hepatocytes near the capsule. In thickened capsules, the noncancerous side consisted primarily of type III collagen and the cancerous side of types I and III collagen. Type I as well as type III collagen was produced by fibroblasts, transitional Ito cells, and hepatocytes. The capsule thus formed is suggested to be part of the defense mechanisms against the growth of hepatocellular carcinoma.
在14例有包膜的肝细胞癌中，我们采用免疫过氧化物酶技术，使用抗I型、III型和IV型胶原抗体、抗层粘连蛋白抗体和抗脯氨酰羟化酶抗体，研究了包膜形成的机制。在包膜的非癌侧以及包膜附近受压肝细胞周围观察到明显的圆形细胞浸润。薄包膜主要由包膜附近数量增加的成纤维细胞、过渡性伊托细胞和肝细胞产生的III型胶原组成。在增厚的包膜中，非癌侧主要由III型胶原组成，癌侧由I型和III型胶原组成。I型和III型胶原均由成纤维细胞、过渡性伊托细胞和肝细胞产生。由此形成的包膜被认为是肝细胞癌生长防御机制的一部分。
