Himeno H, Enzan H, Saibara T, Onishi S, Yamamoto Y
First Department of Internal Medicine, Kochi Medical School, Japan.
J Pathol. 1994 Nov;174(3):217-22. doi: 10.1002/path.1711740311.
The distribution of blood vessels in human hepatocellular carcinoma was studied with the anti-a-smooth muscle actin monoclonal antibody by light and electron microscopy, and with morphometric analysis. a-Smooth muscle actin-positive arterioles were never observed in lobules or pseudolobules of non-cancerous areas, but were frequently seen within hepatocellular carcinomas. Morphometric analysis revealed that most of these arterioles measured between 10 and 25 microns in diameter. The morphology of intratumoural arterioles differed considerably from that of conventional arteries in the portal tracts of the non-cancerous area. The presence of abundant intratumoural arterioles can explain the angiographic hypervascularity of hepatocellular carcinoma and provides a pathological basis for its susceptibility to hypoxia and for arterial embolization as a therapeutic strategy.
采用抗α-平滑肌肌动蛋白单克隆抗体，通过光镜、电镜及形态计量分析，对人肝细胞癌血管分布进行了研究。在非癌区域的小叶或假小叶中从未观察到α-平滑肌肌动蛋白阳性的小动脉，但在肝细胞癌内却经常可见。形态计量分析显示，这些小动脉大多直径在10至25微米之间。肿瘤内小动脉的形态与非癌区域门静脉分支中传统动脉的形态有很大差异。肿瘤内丰富小动脉的存在可解释肝细胞癌血管造影的血管增多现象，并为其对缺氧的易感性及作为治疗策略的动脉栓塞提供病理基础。
