离子辐射下p53应激反应网络的动态模型
A dynamic model for the p53 stress response networks under ion radiation.
作者信息
Qi J-P, Shao S-H, Li D-D, Zhou G-P
机构信息
Bio-Informatics Research Center, Donghua University, Shanghai, China.
出版信息
Amino Acids. 2007 Jul;33(1):75-83. doi: 10.1007/s00726-006-0454-3. Epub 2006 Oct 31.
Abstract
P53 controls the cell cycle arrest and cell apoptosis through interaction with the downstream genes and their signal pathways. To stimulate the investigation into the complicated responses of p53 under the circumstance of ion radiation (IR) in the cellular level, a dynamic model for the p53 stress response networks is proposed. The model can be successfully used to simulate the dynamic processes of generating the double-strand breaks (DSBs) and their repairing, ataxia telangiectasia mutated (ATM) activation, as well as the oscillations occurring in the p53-MDM2 feedback loop.
摘要
p53通过与下游基因及其信号通路相互作用来控制细胞周期停滞和细胞凋亡。为了促进在细胞水平上对p53在离子辐射（IR）情况下复杂反应的研究，提出了一个p53应激反应网络的动态模型。该模型可以成功地用于模拟产生双链断裂（DSB）及其修复、共济失调毛细血管扩张突变（ATM）激活以及p53-MDM2反馈回路中发生的振荡的动态过程。
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