Qi Jinpeng, Ding Yongsheng, Shao Shihuang
College of Information Sciences and Technology, Donghua University, Shanghai 201620, China.
Prog Nat Sci. 2009 Oct 10;19(10):1349-1356. doi: 10.1016/j.pnsc.2009.03.008. Epub 2009 Aug 5.
Under acute perturbations from the outside, cells can trigger self-defensive mechanisms to fight against genome stress. To investigate the cellular response to continuous ion radiation (IR), a dynamic model for p53 stress response networks at the cellular level is proposed. The model can successfully be used to simulate the dynamic processes of double-strand breaks (DSBs) generation and their repair, switch-like ataxia telangiectasia mutated (ATM) activation, oscillations occurring in the p53-MDM2 feedback loop, as well as toxins elimination triggered by p53 stress response networks. Especially, the model can predict the plausible outcomes of cellular response under different IR dose regimes.
在外界的急性扰动下，细胞可以触发自我防御机制来对抗基因组应激。为了研究细胞对连续离子辐射（IR）的反应，提出了一个细胞水平的p53应激反应网络动态模型。该模型可以成功地用于模拟双链断裂（DSB）产生及其修复的动态过程、类似开关的共济失调毛细血管扩张突变（ATM）激活、p53-MDM2反馈回路中发生的振荡，以及p53应激反应网络触发的毒素清除。特别是，该模型可以预测不同IR剂量方案下细胞反应的可能结果。
