基于伪氨基酸组成预测膜蛋白类型的密度相似性应用。
Application of density similarities to predict membrane protein types based on pseudo-amino acid composition.
机构信息
Department of Statistics, Faculty of Science, Shiraz University, Shiraz, Iran.
出版信息
J Theor Biol. 2011 May 7;276(1):132-7. doi: 10.1016/j.jtbi.2011.01.048. Epub 2011 Feb 4.
Abstract
Cell membranes provide integrity of living cells. Although the stability of biological membrane is maintained by the lipid bilayer, membrane proteins perform most of the specific functions such as signal transduction, transmembrane transport, etc. Then it is plausible membrane proteins being attractive drug targets. In this article, based on the concept of using the pseudo-amino acid composition to define a protein, three different density similarities are developed for predicting the membrane protein type. The predicted results showed that the proposed approach can remarkably improve the accuracy, and might become a useful tool for predicting the other attributes of proteins as well.
摘要
细胞膜为活细胞提供了完整性。尽管生物膜的稳定性是由脂质双层维持的，但膜蛋白执行着大多数特定的功能，如信号转导、跨膜运输等。因此，膜蛋白成为有吸引力的药物靶点是合理的。在本文中，基于使用伪氨基酸组成来定义蛋白质的概念，开发了三种不同的密度相似度来预测膜蛋白类型。预测结果表明，所提出的方法可以显著提高准确性，并且可能成为预测蛋白质其他属性的有用工具。
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