Gillespie Iain A, McLauchlin Jim, Grant Kathie A, Little Christine L, Mithani Vina, Penman Celia, Lane Christopher, Regan Martyn
Health Protection Agency, London, United Kingdom.
Emerg Infect Dis. 2006 Sep;12(9):1361-6. doi: 10.3201/eid1209.051657.
Microbiologic and epidemiologic data on 1,933 cases of human listeriosis reported in England and Wales from 1990 to 2004 were reviewed. A substantial increase in incidence occurred from 2001 to 2004. Ten clusters (60 cases), likely to represent common-source outbreaks, were detected. However, these clusters did not account for the upsurge in incidence, which occurred sporadically, predominantly in patients > or =60 years of age with bacteremia and which was independent of sex; regional, seasonal, ethnic, or socioeconomic differences; underlying conditions; or Listeria monocytogenes subtype. The reasons for the increase are not known, but since multiple L. monocytogenes strains were responsible, this upsurge is unlikely to be due to a common-source outbreak. In the absence of risk factors for listeriosis in this emerging at-risk sector of the population, dietary advice on avoiding high-risk foods should be provided routinely to the elderly and immunocompromised, not just to pregnant women.
对1990年至2004年在英格兰和威尔士报告的1933例人类李斯特菌病病例的微生物学和流行病学数据进行了回顾。2001年至2004年发病率大幅上升。检测到10个聚集性病例（60例），可能代表共同来源的暴发。然而，这些聚集性病例并不能解释发病率的激增，发病率激增是散发性的，主要发生在年龄≥60岁的菌血症患者中，且与性别、地区、季节、种族或社会经济差异、基础疾病或单核细胞增生李斯特菌亚型无关。发病率上升的原因尚不清楚，但由于多种单核细胞增生李斯特菌菌株都有责任，这种激增不太可能是由于共同来源的暴发。鉴于这一新兴高危人群中不存在李斯特菌病的危险因素，应常规向老年人和免疫功能低下者提供避免食用高危食品的饮食建议，而不仅仅是向孕妇提供。
