Akhalaya M Ya, Baizhumanov A A, Graevskaya E E
Laboratory of Radiation Biophysics, Department of Biophysics, Biological Faculty, M. V. Lomonosov Moscow State University.
Bull Exp Biol Med. 2006 Mar;141(3):328-30. doi: 10.1007/s10517-006-0162-8.
We studied the effects of taurine, carnosine, and casomorphine on histamine release from rat peritoneal mast cells induced by compound 48/80 and ionophore A23187. Differences were revealed in the effect of the test preparations. Taurine inhibited histamine release induced by ionophore A23187, but not by compound 48/80. Carnosine abolished the stimulatory effect of compound 48/80 on histamine release, but did not modulate the effect of ionophore A23187. Casomorphine inhibited histamine release induced by ionophore A23187, but potentiated the effect of compound 48/80. The mechanisms for these effects are discussed.
我们研究了牛磺酸、肌肽和酪蛋白吗啡对化合物48/80和离子载体A23187诱导的大鼠腹膜肥大细胞组胺释放的影响。结果显示，受试制剂的作用存在差异。牛磺酸抑制离子载体A23187诱导的组胺释放，但不抑制化合物48/80诱导的组胺释放。肌肽消除了化合物48/80对组胺释放的刺激作用，但不调节离子载体A23187的作用。酪蛋白吗啡抑制离子载体A23187诱导的组胺释放，但增强了化合物48/80的作用。文中讨论了这些作用的机制。
