化合物48/80或A23187诱导的小鼠腹腔肥大细胞组胺释放的品系差异

Strain differences in histamine release from mouse peritoneal mast cells induced by compound 48/80 or A23187.

作者信息

Toda S, Kimura M, Tohya K

机构信息

Central Animal Laboratory, Kansai College of Acupuncture Medicine, Osaka, Japan.

出版信息

Jikken Dobutsu. 1989 Apr;38(2):135-7. doi: 10.1538/expanim1978.38.2_135.

DOI:10.1538/expanim1978.38.2_135

PMID:2472970

Abstract

Strain differences among BALB/c, BDF1, CDF1, C3 H/He, C57 BL/6, DBA/2, ddy and ICR mice were investigated with respect to the ratios of histamine release from mouse peritoneal mast cells induced by compound 48/80, a Ca2+ dependent histamine releaser, and the Ca2+ ionophore A23187. The ratios of histamine release from mouse peritoneal mast cells induced by compound 48/80 were found to be high in BALB/c, ddY and ICR mice, but low in BDF1, CDF1, C3 H/He, C57 BL/6 and DBA/2 mice. Those induced by Ca2+ ionophore A23187 were high in BALB/c, BDF1, CDF1, C3 H/He, DBA2, ddy and ICR mice but low in C57 BL/6 mice. These results indicate that differences in histamine release from mouse peritoneal mast cells are strain dependent.

摘要

研究了BALB/c、BDF1、CDF1、C3H/He、C57BL/6、DBA/2、ddy和ICR小鼠之间的品系差异，这些差异涉及化合物48/80（一种依赖Ca2+的组胺释放剂）和Ca2+离子载体A23187诱导的小鼠腹腔肥大细胞组胺释放比率。发现化合物48/80诱导的小鼠腹腔肥大细胞组胺释放比率在BALB/c、ddY和ICR小鼠中较高，而在BDF1、CDF1、C3H/He、C57BL/6和DBA/2小鼠中较低。Ca2+离子载体A23187诱导的组胺释放比率在BALB/c、BDF1、CDF1、C3H/He、DBA2、ddy和ICR小鼠中较高，而在C57BL/6小鼠中较低。这些结果表明，小鼠腹腔肥大细胞组胺释放的差异是品系依赖性的。