Piantelli M, Maggiano N, Larocca L M, Ricci R, Ranelletti F O, Lauriola L, Capelli A
Istituti di Anatomia Patologica, Università Cattolica S. Coure, Roma, Italy.
Brain Behav Immun. 1990 Sep;4(3):189-97. doi: 10.1016/0889-1591(90)90022-i.
The outer cortex of the human thymus contains a one- to two-cell-thick layer that is immunoreactive with antisera against beta-endorphin, (Leu)- and (Met)-enkephalin, bombesin, and substance P. The epithelial nature of these immunostained cells is revealed by immunoelectron microscopic studies showing the presence of desmosomal junctions. The presence of peptide-containing cells in the outer cortex, where the most immature and recently immigrated thymocytes are found, emphasizes the role of neuropeptides in regulating the microenvironment for T cell development.
人类胸腺的外层皮质包含一层一到两个细胞厚度的结构，它与抗β-内啡肽、亮氨酸脑啡肽、甲硫氨酸脑啡肽、蛙皮素和P物质的抗血清发生免疫反应。免疫电子显微镜研究显示存在桥粒连接，从而揭示了这些免疫染色细胞的上皮性质。在发现最不成熟和最近迁入的胸腺细胞的外层皮质中存在含肽细胞，这强调了神经肽在调节T细胞发育微环境中的作用。
