小鼠对蛋白脂质载脂蛋白及其致脑炎性决定因素的易感性。

Susceptibility to proteolipid apoprotein and its encephalitogenic determinants in mice.

作者信息

Endoh M, Kunishita T, Nihei J, Nishizawa M, Tabira T

机构信息

Division of Demyelinating Disease and Aging, National Institute of Neuroscience, Tokyo, Japan.

出版信息

Int Arch Allergy Appl Immunol. 1990;92(4):433-8. doi: 10.1159/000235176.

DOI:10.1159/000235176

PMID:1707404

Abstract

We investigated in mice strain differences in induction of experimental allergic encephalomyelitis by proteolipid apoprotein and studied encephalitogenic determinants. SJL/J, C3H/He, CBA/J and A/J mice were high responders, BALB/c and AKR/J mice were moderately susceptible, and DBA/2, B6 and congenic strains of B10 background were low responders. Synthetic peptide 136-150 was encephalitogenic for SJL/J mice, and 215-232 was encephalitogenic for C3H/He mice. These encephalitogenic derterminants are present in the extracellular portion of proteolipid apoprotein in myelin.

摘要

我们在小鼠中研究了脂蛋白载脂蛋白诱导实验性变应性脑脊髓炎的品系差异，并研究了致脑炎决定簇。SJL/J、C3H/He、CBA/J和A/J小鼠是高反应者，BALB/c和AKR/J小鼠中度易感，而DBA/2、B6和B10背景的同源品系是低反应者。合成肽136 - 150对SJL/J小鼠有致脑炎作用，215 - 232对C3H/He小鼠有致脑炎作用。这些致脑炎决定簇存在于髓磷脂中脂蛋白载脂蛋白的细胞外部分。