Kirshner Howard S, Lavin Patrick J M
Department of Neurology, Vanderbilt University School of Medicine, 2311 Pierce Avenue, Nashville, TN 37232-3375, USA.
Curr Neurol Neurosci Rep. 2006 Nov;6(6):477-80. doi: 10.1007/s11910-006-0049-0.
Posterior cortical atrophy is a striking clinical syndrome in which a dementing illness begins with visual symptoms. Initially, the problem may seem to be loss of elementary vision, but over time the patient develops features of visual agnosia, topographical difficulty, optic ataxia, simultanagnosia, ocular apraxia (Balint's syndrome), alexia, acalculia, right-left confusion, and agraphia (Gerstmann's syndrome), and later a more generalized dementia. Occasional patients have visual hallucinations and signs of Parkinson's disease or Lewy body dementia. A number of different neuropathologic disorders are associated with posterior cortical atrophy.
后部皮质萎缩是一种显著的临床综合征，其中痴呆性疾病始于视觉症状。起初，问题可能看似是基本视力丧失，但随着时间推移，患者会出现视觉失认、地形定向障碍、视觉性共济失调、同时失认、眼球失用（巴林特综合征）、失读症、失算症、左右定向障碍和失写症（格斯特曼综合征）等特征，随后会出现更广泛的痴呆。少数患者有视幻觉以及帕金森病或路易体痴呆的体征。许多不同的神经病理学障碍与后部皮质萎缩有关。
