Borza I, Greiner I, Kolok S, Galgóczy K, Ignácz-Szendrei Gy, Horváth Cs, Farkas S, Gáti T, Háda V, Domány Gy
Gedeon Richter Ltd, Budapest, Hungary.
Pharmazie. 2006 Sep;61(9):799-800.
A novel series of benzoyl urea derivatives was prepared and identified as NR2B selective NMDA receptor antagonists. The influence of the substitution of the piperidine ring on the biological activity of the compounds was studied. Compound 9 was active in the formalin test in mice.
制备了一系列新型苯甲酰脲衍生物，并将其鉴定为NR2B选择性N-甲基-D-天冬氨酸受体拮抗剂。研究了哌啶环取代对化合物生物活性的影响。化合物9在小鼠福尔马林试验中具有活性。
