Aspenström Pontus, Fransson Asa, Richnau Ninna
Ludwig Institute for Cancer Research, Biomedical Center, Uppsala University, SE-751 24 Uppsala, Sweden.
Trends Biochem Sci. 2006 Dec;31(12):670-9. doi: 10.1016/j.tibs.2006.10.001. Epub 2006 Oct 30.
Pombe Cdc15 homology (PCH) proteins have emerged in many species as important coordinators of signalling pathways that regulate actomyosin assembly and membrane dynamics. For example, the prototype PCH protein, Cdc15p of Schizosaccharomyces pombe, has a role in assembly of the contractile ring, which is needed to separate dividing cells. Recently, mammalian PCH proteins have been found to bind phospholipids and to participate in membrane deformation. These findings suggest that PCH proteins are crucial linkers of membrane dynamics and actin polymerization, for example, during the internalization of transmembrane receptors. Intriguingly, some members of the PCH protein family are mutated in neurodegenerative and inflammatory diseases, which has implications for the identification of cures for such disorders.
粟酒裂殖酵母Cdc15同源（PCH）蛋白在许多物种中已成为调节肌动球蛋白组装和膜动力学的信号通路的重要协调因子。例如，原型PCH蛋白，即粟酒裂殖酵母的Cdc15p，在收缩环的组装中起作用，而收缩环是分离分裂细胞所必需的。最近，已发现哺乳动物PCH蛋白可结合磷脂并参与膜变形。这些发现表明，PCH蛋白是膜动力学和肌动蛋白聚合的关键连接物，例如在跨膜受体的内化过程中。有趣的是，PCH蛋白家族的一些成员在神经退行性疾病和炎症性疾病中发生了突变，这对寻找此类疾病的治疗方法具有启示意义。
