Chitu Violeta, Stanley E Richard
Department of Developmental Biology and Molecular Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York, NY 10461, USA.
Trends Cell Biol. 2007 Mar;17(3):145-56. doi: 10.1016/j.tcb.2007.01.003. Epub 2007 Feb 12.
Cellular adhesion, motility, endocytosis, exocytosis and cytokinesis involve the coordinated reorganization of the cytoskeleton and of the plasma membrane. The 'Pombe Cdc15 homology' (PCH) family of adaptor proteins has recently been shown to coordinate the membrane and cytoskeletal dynamics involved in these processes by curving membranes, recruiting dynamin and controlling the architecture of the actin cytoskeleton. Mutations in PCH family members or proteins that interact with them are associated with autoinflammatory, neurological or neoplastic diseases. Here, we review the nature, actions and disease associations of the vertebrate PCH family members, highlighting their fundamental roles in the regulation of processes involving membrane-cytoskeletal interactions.
细胞黏附、运动、内吞作用、胞吐作用和胞质分裂都涉及细胞骨架和质膜的协同重组。衔接蛋白的“粟酒裂殖酵母Cdc15同源物”（PCH）家族最近被证明可通过使膜弯曲、募集发动蛋白并控制肌动蛋白细胞骨架的结构，来协调这些过程中涉及的膜和细胞骨架动力学。PCH家族成员或与其相互作用的蛋白质中的突变与自身炎症性、神经或肿瘤性疾病相关。在这里，我们综述脊椎动物PCH家族成员的性质、作用和疾病关联，强调它们在涉及膜-细胞骨架相互作用的过程调节中的基本作用。
