The Sainsbury Laboratory, University of East Anglia, Norwich, UK.
Cytoskeleton (Hoboken). 2023 Jul-Aug;80(7-8):242-253. doi: 10.1002/cm.21765. Epub 2023 Jun 2.
Fungal pathogens undergo specific morphogenetic transitions in order to breach the outer surfaces of plants and invade the underlying host tissue. The ability to change cell shape and switch between non-polarised and polarised growth habits is therefore critical to the lifestyle of plant pathogens. Infection-related development involves remodelling of the cytoskeleton, plasma membrane and cell wall at specific points during fungal pathogenesis. Septin GTPases are components of the cytoskeleton that play pivotal roles in actin remodelling, micron-scale plasma membrane curvature sensing and cell polarity. Septin assemblages, such as rings, collars and gauzes, are known to have important roles in cell shape changes and are implicated in formation of specialised infection structures to enter plant cells. Here, we review and compare the reported functions of septins of plant pathogenic fungi, with a special focus on invasive growth. Finally, we discuss septins as potential targets for broad-spectrum antifungal plant protection strategies.
真菌病原体经历特定的形态发生转变，以便突破植物的外表面并侵入下面的宿主组织。因此，改变细胞形状并在非极化和极化生长习性之间切换的能力对于植物病原体的生活方式至关重要。感染相关的发育涉及在真菌发病过程中的特定时间点重塑细胞骨架、质膜和细胞壁。GTP 结合的 septin 是细胞骨架的组成部分，在肌动蛋白重塑、微米级质膜曲率感应和细胞极性方面发挥着关键作用。众所周知，septin 组装体，如环、领和网，在细胞形状变化中具有重要作用，并参与形成专门的感染结构以进入植物细胞。在这里，我们回顾和比较了植物病原真菌 septin 的报道功能，特别关注侵袭性生长。最后，我们讨论了 septin 作为广谱抗真菌植物保护策略的潜在目标。
