Hajilooi M, Rafiei A, Reza Zadeh M, Tajik N
Department of Immunology, Molecular Medicine Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
Tissue Antigens. 2006 Oct;68(4):331-4. doi: 10.1111/j.1399-0039.2006.00668.x.
The aim of this study was to determine the influence of the polymorphism within the intron 2 of the interleukin-1 receptor antagonist gene (IL-1Ra) on the susceptibility to or development of brucellosis. A total of 255 patients with brucellosis and 162 healthy volunteers were genotyped for polymorphisms in intron 2 of the IL-1Ra gene. The frequency of allele 2 of the IL-1Ra gene was significantly higher in patients with brucellosis compared with the controls (24.5% vs 18.5%, P = 0.03). Although the heterozygosity was more prevalent in patients than in control individuals, it did not have any statistical significance (P = 0.1). Alleles 3, 4, and 5 were absent in our study population. This work is the first that verifies a significant association between genetic polymorphism of IL-1Ra and susceptibility to brucellosis.
本研究的目的是确定白细胞介素-1受体拮抗剂基因（IL-1Ra）内含子2中的多态性对布鲁氏菌病易感性或发病的影响。对总共255例布鲁氏菌病患者和162名健康志愿者进行了IL-1Ra基因内含子2多态性的基因分型。与对照组相比，布鲁氏菌病患者中IL-1Ra基因2等位基因的频率显著更高（24.5%对18.5%，P = 0.03）。尽管杂合性在患者中比在对照个体中更普遍，但没有统计学意义（P = 0.1）。等位基因3、4和5在我们的研究人群中不存在。这项工作首次证实了IL-1Ra基因多态性与布鲁氏菌病易感性之间存在显著关联。
