Larson Mark K, Watson Steve P
Centre for Cardiovascular Sciences, Institute for Biomedical Research, Division of Medical Sciences, The Medical School, University of Birmingham, Birmingham, UK B15 2TT, UK.
Platelets. 2006 Nov;17(7):435-40. doi: 10.1080/09537100600772637.
Megakaryocytes have long been observed to form abundant filamentous extensions called proplatelets. A strong body of evidence strongly suggests these proplatelets are the mechanism by which platelets are released into the vasculature. Despite the recent advances in understanding proplatelet architecture, surprisingly little attention has been paid to identifying the ways in which the bone marrow environment regulates proplatelet formation. This review summarises this field and how these findings suggest a spatial and temporal regulation to ensure that platelets are produced in the correct location.
长期以来，人们观察到巨核细胞会形成大量称为前血小板的丝状延伸物。大量有力证据强烈表明，这些前血小板是血小板释放到脉管系统中的机制。尽管最近在理解前血小板结构方面取得了进展，但令人惊讶的是，在确定骨髓环境调节前血小板形成的方式方面却很少受到关注。这篇综述总结了该领域以及这些发现如何表明存在空间和时间调节，以确保血小板在正确的位置产生。
