Manning Donal, Todd Peter, Maxwell Melanie, Jane Platt Mary
Donal Manning, Department of Paediatrics, Arrowe Park Hospital, Wirral, Merseyside CH49 5PE, UK.
Arch Dis Child Fetal Neonatal Ed. 2007 Sep;92(5):F342-6. doi: 10.1136/adc.2006.105361. Epub 2006 Oct 30.
To determine the incidence of severe hyperbilirubinaemia in the newborn, and to identify associated clinical and demographic variables, and short-term outcomes.
Prospective, population-based study.
UK and Republic of Ireland, between 1 May 2003 and 31 May 2005.
Infants in the first month of life with severe hyperbilirubinaemia (maximum unconjugated serum bilirubin >/=510 micromol/l).
108 infants met the case definition, 106 from the UK and 2 from the Republic of Ireland. The UK incidence of severe hyperbilirubinaemia was 7.1/100 000 live births (95% CI 5.8 to 8.6). Only 20 cases presented in hospital; 88 were admitted with severe jaundice. 64 (60.4%) cases were male, and 56 (51.8%) were of ethnic minority origin. 87 (80.5%) cases were exclusively breast fed. Co-morbidity included haemolysis, dehydration, infection and bruising. 14 infants showed evidence of bilirubin encephalopathy, of whom 3 died. The UK incidence of bilirubin encephalopathy was 0.9/100 000 live births (95% CI 0.46 to 1.5).
This is the first large, prospective, population-based study of the incidence of severe hyperbilirubinaemia in the newborn. The clinical and demographic associations, and short-term outcomes identified, are the same as those reported recently in North America and Europe.
确定新生儿严重高胆红素血症的发病率，识别相关的临床和人口统计学变量以及短期结局。
前瞻性、基于人群的研究。
2003年5月1日至2005年5月31日期间的英国和爱尔兰共和国。
出生后第一个月内患有严重高胆红素血症（血清未结合胆红素最大值≥510微摩尔/升）的婴儿。
108名婴儿符合病例定义，其中106名来自英国，2名来自爱尔兰共和国。英国严重高胆红素血症的发病率为7.1/10万活产（95%可信区间5.8至8.6）。仅20例在医院就诊；88例因严重黄疸入院。64例（60.4%）为男性，56例（51.8%）为少数民族。87例（80.5%）为纯母乳喂养。合并症包括溶血、脱水、感染和瘀伤。14名婴儿有胆红素脑病的证据，其中3例死亡。英国胆红素脑病的发病率为0.9/10万活产（95%可信区间0.46至1.5）。
这是第一项关于新生儿严重高胆红素血症发病率的大型、前瞻性、基于人群的研究。所确定的临床和人口统计学关联以及短期结局与北美和欧洲最近报道的相同。
