van Os Jim, Drukker Marjan, à Campo Joost, Meijer Jaap, Bak M, Delespaul Philippe
Department of Psychiatry and Neuropsychology, Maastricht University, P.O. Box 616 DRT 10, 6200 MD Maastricht, the Netherlands.
Am J Psychiatry. 2006 Nov;163(11):2000-2. doi: 10.1176/ajp.2006.163.11.2000.
Remission criteria for schizophrenia have been proposed, consisting of a time criterion and a symptomatic remission criterion. With longitudinal data of a representative patient group (N=317; median follow-up: 1,132 days), validity of the symptomatic remission criterion was investigated.
In a group of 145 patients meeting the symptomatic remission criterion at baseline and a group of 172 patients not meeting it at baseline, change over time in remission status was examined in relation to change in various functional outcomes.
In both groups, change over time with the symptomatic remission criterion was associated with substantial changes in unmet needs, Global Assessment of Functioning scale scores, satisfaction with services and, to a lesser extent, quality of life. Changing the symptomatic remission criterion to include depression and suicidality did not affect the results.
The proposed symptomatic remission criterion has clinical validity and represents the right balance between parsimony and inclusiveness.
已提出精神分裂症的缓解标准，包括时间标准和症状缓解标准。利用一组具有代表性的患者群体（N = 317；中位随访时间：1132天）的纵向数据，对症状缓解标准的有效性进行了研究。
在一组基线时符合症状缓解标准的145例患者和一组基线时不符合该标准的172例患者中，研究缓解状态随时间的变化与各种功能结局变化之间的关系。
在两组中，症状缓解标准随时间的变化与未满足需求、功能总体评定量表评分、服务满意度以及在较小程度上与生活质量的显著变化相关。将症状缓解标准改为纳入抑郁和自杀倾向并不影响结果。
所提出的症状缓解标准具有临床有效性，代表了简约性和包容性之间的恰当平衡。
