Herida M, de Barbeyrac B, Sednaoui P, Scieux C, Lemarchand N, Kreplak G, Clerc M, Timsit J, Goulet V, Desenclos J C, Semaille Caroline
Institut de veille sanitaire, Saint-Maurice, France.
Euro Surveill. 2006 Sep;11(9):155-6.
Lymphogranuloma venereum (LGV) is a sexually transmitted infection (STI) caused by Chlamydia trachomatis strains belonging to the L1, L2 or L3 genotype. An alert about an outbreak of LGV among MSM in the Netherlands was published in January 2004. The first cases of rectal LGV in France were retrospectively diagnosed in March 2004 and sentinel surveillance for LGV was implemented in April 2004. Most of the participating centres were located in the cities of Paris and Bordeaux. Only confirmed rectal LGV cases were included in the surveillance. Rectal specimens from men that were found to be positive for C trachomatis by PCR were sent to the National Reference Centre for Chlamydia infection for genotyping. Simple epidemiological data provided by clinicians and genotyping results were sent to the Institut de Veille Sanitaire (InVS) where data were anonymously recorded. A total of 328 C. trachomatis rectal strains isolated in men were genotyped by the end of December 2005. Of these, 244 (74%) were LGV strains belonging to the L2 genotype. No L1 or L3 C. trachomatis genotype was found. Diagnosis was made retrospectively for 46 cases. The median age of patients with LGV was 39 years. HIV status was known for 96 patients: 82/96 (85%) were HIV-infected. Most LGV cases were diagnosed in the Paris area (92%). Among the remaining 26% C. trachomatis strains, genotypes Da and G were the most frequent. As with syphilis in recent years, the emergence of LGV in Europe is mainly affecting HIV-infected MSM. The screening and treatment of STIs should be included in the clinical follow-up of all HIV-infected MSM.
性病性淋巴肉芽肿（LGV）是一种性传播感染（STI），由沙眼衣原体L1、L2或L3基因型菌株引起。2004年1月发布了关于荷兰男男性行为者中LGV暴发的警报。法国首例直肠LGV病例于2004年3月进行回顾性诊断，并于2004年4月实施LGV哨点监测。大多数参与中心位于巴黎和波尔多市。监测仅纳入确诊的直肠LGV病例。通过聚合酶链反应（PCR）检测发现沙眼衣原体呈阳性的男性直肠标本被送往国家衣原体感染参考中心进行基因分型。临床医生提供的简单流行病学数据和基因分型结果被发送至法国卫生监测研究所（InVS），数据在那里进行匿名记录。截至2005年12月底，共对328株从男性中分离出的沙眼衣原体直肠菌株进行了基因分型。其中，244株（74%）为属于L2基因型的LGV菌株。未发现L1或L3沙眼衣原体基因型。46例病例为回顾性诊断。LGV患者的中位年龄为39岁。96例患者的艾滋病毒感染状况已知：82/96（85%）为艾滋病毒感染者。大多数LGV病例在巴黎地区被诊断（92%）。在其余26%的沙眼衣原体菌株中，Da和G基因型最为常见。与近年来的梅毒情况一样，LGV在欧洲的出现主要影响艾滋病毒感染的男男性行为者。所有艾滋病毒感染的男男性行为者的临床随访中都应包括性传播感染的筛查和治疗。
