Fujishima Hiroshi, Fukagawa Kazumi, Takano Yoji, Okamoto Shigeki, Nakagawa Yayoi, Uchio Eiichi, Yokoi Norihiko, Fukushima Atsuki, Takamura Etsuko
Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan.
Allergol Int. 2006 Sep;55(3):301-3. doi: 10.2332/allergolint.55.301.
We investigated the early efficacy of topical levocabastine, an H(1) histamine-receptor antagonist, in improving the clinical symptoms of allergic conjunctivitis.
Thirty-six patients with allergic conjunctivitis were enrolled. One drop of levocabastine was instilled in one eye and one drop of artificial tears in the contralateral eye. Clinical examinations were performed before, and 15 and 30 minutes after instillation. Symptoms of itching and signs of injection were assessed at each time point.
Both levocabastine and artificial tears resulted in a statistically significant reduction in ocular itching. However, levocabastine was significantly more effective.
Although artificial tears had a positive effect in reducing symptoms of allergic conjunctivitis, by the washing out of allergens, levocabastine was more effective than artificial tears in controlling acute symptoms of allergic conjunctivitis, demonstrating that the selective H1 histamine-receptor antagonist action of levocabastine is rapidly effective in a clinical setting.
我们研究了H(1)组胺受体拮抗剂左卡巴斯汀局部用药改善过敏性结膜炎临床症状的早期疗效。
招募36例过敏性结膜炎患者。一只眼滴入一滴左卡巴斯汀，对侧眼滴入一滴人工泪液。在滴药前、滴药后15分钟和30分钟进行临床检查。在每个时间点评估瘙痒症状和结膜充血体征。
左卡巴斯汀和人工泪液均使眼部瘙痒在统计学上显著减轻。然而，左卡巴斯汀的效果明显更好。
虽然人工泪液通过冲洗过敏原对减轻过敏性结膜炎症状有积极作用，但左卡巴斯汀在控制过敏性结膜炎急性症状方面比人工泪液更有效，表明左卡巴斯汀的选择性H1组胺受体拮抗作用在临床环境中起效迅速。
