Sengupta Sarojini M, Grizenko Natalie, Schmitz Norbert, Schwartz George, Ben Amor Leila, Bellingham Johanne, DE Guzman Rosherrie, Polotskaia Anna, Ter Stepanian Marina, Thakur Geeta, Joober Ridha
Drs. Sengupta, Ben Amor, and Joober are with the Department of Human Genetics, Drs. Grizenko and Joober and Mr. Schwartz are with the Department of Psychiatry, Dr. Joober and Ms. Thakur are with the Department of Neurology and Neurosurgery, McGill University; and Drs. Sengupta, Schmitz, and Joober, Mr. Schwartz, Ms. Bellingham, Ms. de Guzman, Ms. Polotskaia, and Ms. Ter Stepanian are with Douglas Hospital Research Centre, Montreal, Quebec, Canada.
Drs. Sengupta, Ben Amor, and Joober are with the Department of Human Genetics, Drs. Grizenko and Joober and Mr. Schwartz are with the Department of Psychiatry, Dr. Joober and Ms. Thakur are with the Department of Neurology and Neurosurgery, McGill University; and Drs. Sengupta, Schmitz, and Joober, Mr. Schwartz, Ms. Bellingham, Ms. de Guzman, Ms. Polotskaia, and Ms. Ter Stepanian are with Douglas Hospital Research Centre, Montreal, Quebec, Canada..
J Am Acad Child Adolesc Psychiatry. 2006 Nov;45(11):1363-1369. doi: 10.1097/01.chi.0000251212.44491.46.
In a recent study, Thapar and colleagues reported that COMT "gene variant and birth weight predict early-onset antisocial behavior in children" with attention-deficit/hyperactivity disorder. We have attempted to replicate these findings in a group of ADHD children using a similar research design.
Children (n=191) between 6 and 12 years of age who were diagnosed with ADHD were included in the study. Conduct disorder was diagnosed according to DSM-IV criteria based on clinical evaluation and a structured interview (Diagnostic Interview Schedule for Children-IV). The mother's report on the child's birth weight was used in the analysis. Logistic regression analysis, with genotype and birth weight as independent variables and DSM-IV conduct disorder as the dependent variable, was conducted.
No significant main effects of genotype and birth weight or interaction effects on conduct disorder were observed.
In this sample of children diagnosed with ADHD, we find no association between the COMT ValMet gene variant, birth weight, and conduct disorder. Further investigations are required before using birth weight and COMT genotype as predictors of conduct disorder in children with attention-deficit/hyperactivity disorder, especially given the societal and legal ramifications of conduct disorder.
在最近的一项研究中，萨帕尔及其同事报告称，儿茶酚-O-甲基转移酶（COMT）“基因变异和出生体重可预测患有注意力缺陷多动障碍（ADHD）儿童的早发性反社会行为”。我们试图采用类似的研究设计，在一组ADHD儿童中复制这些研究结果。
本研究纳入了191名年龄在6至12岁之间、被诊断患有ADHD的儿童。根据《精神疾病诊断与统计手册》第四版（DSM-IV）标准，通过临床评估和结构化访谈（儿童诊断访谈量表第四版）对品行障碍进行诊断。分析中采用母亲报告的孩子出生体重。以基因型和出生体重作为自变量，以DSM-IV品行障碍作为因变量，进行了逻辑回归分析。
未观察到基因型和出生体重的显著主效应，也未观察到它们对品行障碍的交互效应。
在这个被诊断患有ADHD的儿童样本中，我们发现COMT ValMet基因变异、出生体重与品行障碍之间没有关联。在将出生体重和COMT基因型用作注意力缺陷多动障碍儿童品行障碍的预测指标之前，还需要进一步研究，尤其是考虑到品行障碍的社会和法律影响。
