Bagci Sait, Ercin C Nuri, Yesilova Zeki, Ozcan Ayhan, Degertekin Bulent, Dagalp Kemal
Department of Gastroenterology, Gulhane School of Medicine, Etlik 06018 - Ankara, Turkey.
World J Gastroenterol. 2006 Nov 7;12(41):6707-10. doi: 10.3748/wjg.v12.i41.6707.
To investigate the prevalence of celiac disease serologic markers (antigliadin IgA, IgG, and anti-endomysial IgA) in patients with reflux esophagitis and to detect the relationship between reflux esophagitis and celiac disease (CD).
This study was performed prospectively between January 2003 and January 2004. Sixty-eight adult reflux esophagitis patients and 40 people as control group for symptoms related with gastrointestinal system were enrolled in this study. The diagnostic work-up included an accurate medical history with gastrointestinal symptoms, routine laboratory measurements, the detection of antibodies against gliadin (IgA and IgG) and endomysium (IgA), and an upper endoscopy with postbulbar biopsy.
IgA-AGA and IgG-AGA were positive at 8.8% and 10.3% in patients with reflux esophagitis. In control group, it was found that 10% people had positive IgA-AGA, and 7.5% people had positive IgG-AGA. There was no significant relationship between patients and control group regarding positive IgA-AGA and IgG-AGA. The patients and persons in control group had no positive IgA-EMA. On postbulbar biopsies, no finding was detected concerning celiac disease. There were no symptoms and signs for gluten enteropathy in patients and control group.
This review supports that an association does not exist between celiac disease and reflux esophagitis. We think these diseases exist independently from each other.
调查反流性食管炎患者中乳糜泻血清学标志物（抗麦胶蛋白IgA、IgG和抗肌内膜IgA）的患病率，并检测反流性食管炎与乳糜泻（CD）之间的关系。
本研究于2003年1月至2004年1月前瞻性进行。本研究纳入了68例成年反流性食管炎患者和40例有胃肠道系统相关症状的人作为对照组。诊断检查包括详细的胃肠道症状病史、常规实验室检查、抗麦胶蛋白抗体（IgA和IgG）及抗肌内膜抗体（IgA）检测，以及球后活检的上消化道内镜检查。
反流性食管炎患者中IgA-AGA和IgG-AGA阳性率分别为8.8%和10.3%。在对照组中，发现10%的人IgA-AGA阳性，7.5%的人IgG-AGA阳性。患者与对照组在IgA-AGA和IgG-AGA阳性方面无显著关系。患者和对照组中均无IgA-EMA阳性。在球后活检中，未发现与乳糜泻相关的表现。患者和对照组中均无麸质肠病的症状和体征。
本综述支持乳糜泻与反流性食管炎之间不存在关联。我们认为这些疾病相互独立存在。
