Li Wen-Zhe, Lu Jie, Sun Xiao-Yu, Wang Shi-Long, Ni Ya-Ming, Zhu Wen-Si
College of Life Science and Technology of Tongji University, Shanghai 200092, China.
Zhong Yao Cai. 2006 Aug;29(8):816-8.
To study the effects of water and alcohol extracts of several Chinese herbal medicines and other medicines on alcohol dehydrogenase activity in order to provide enzymology basis on new medicine.
Water or alcohol extracts of Chinese herbal medicine and other medicine were tested on the effects of alcohol dehydrogenase activity by Valle and Hoch method.
Among them, 8 were found to have the effect of activation on alcohol dehydrogenase. They were water extracts of Amomum kravanh and Pueraria flowers, the alcohol extracts of Pueraria flowers, compound hepatcare Chinese medicine and compound Pueraria medicine, L-cysteine, notoginseng saponin. Others had inhibiting action.
To decrease alcohol concentration in the body through activating the activity of ADH may be one of the mechanisms for some traditional Chinese herbal medicine in neutralizing the effect of alcohol drink.
研究几种中草药及其他药物的水提取物和醇提取物对乙醇脱氢酶活性的影响，为新药研发提供酶学依据。
采用瓦勒和霍赫法检测中草药及其他药物的水提取物或醇提取物对乙醇脱氢酶活性的影响。
其中8种被发现具有激活乙醇脱氢酶的作用。它们是阳春砂水提取物、葛花水提取物、葛花醇提取物、复方肝康中药、复方葛根中药、L-半胱氨酸、三七皂苷。其他的则有抑制作用。
通过激活乙醇脱氢酶活性来降低体内酒精浓度可能是某些传统中草药中和酒精饮品作用的机制之一。
