Li Yan-ju, Liu Hui, Wang Hong-fei, Guo Yue-qiu
Department of Clinic Immunology, Dalian Medical University, Dalian 116027, China.
Zhongguo Zhong Yao Za Zhi. 2007 Sep;32(17):1783-6.
Intends to create mathematical model and analysis of correlation between Chinese medicinal characteristics and immunoregulatory activity based on literature informatics.
The numbers of the Chinese medicines with immune effects were worked out within the framework of "The China Pharmacopeia" of 2005 edition, from the literature publicized since 1980. The correlation and mathematical model were figured out between Chinese medicinal characteristics including biological classification, different tastes, channel tropism as well as the parts used and immunoregulatory activity based on the statistical software SPSS.
The results showed that the immunoregulatory activity was related to the five tastes of Chinese medicines, and the pungent medicines had less immune effect. The Chinese medicines of underground parts had more immune effect compared with other parts of the medicine. Medicines acting upon heart and kidneys were more powerful as for the immune effects (P <0.05). The coincidence was 74.7% between mathematical computing and original classification.
There are correlations,between Chinese medicinal characteristics and immunoregulatory activity. The mathematical model based on these results can be used for immunopharmacology.
基于文献信息学创建中药特性与免疫调节活性之间的数学模型并分析其相关性。
在2005年版《中国药典》框架内，统计1980年以来发表文献中具有免疫作用的中药数量。基于统计软件SPSS，计算中药特性（包括生物分类、五味、归经以及入药部位）与免疫调节活性之间的相关性及数学模型。
结果表明，免疫调节活性与中药五味有关，辛味药免疫作用较弱。与其他入药部位相比，地下部分入药的中药免疫作用更强。作用于心、肾经的药物免疫作用更强（P<0.05）。数学计算与原始分类的符合率为74.7%。
中药特性与免疫调节活性之间存在相关性。基于这些结果建立的数学模型可用于免疫药理学研究。
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