Yamamura Y, Yamaguchi N, Hongo M, Imanishi J
Department of Microbiology, Kyoto Prefectural University of Medicine, Japan.
Hum Cell. 1990 Jun;3(2):113-7.
A new human fibroblast-producing factor which degenerates human tumor cells in vitro was found and designated as tumor-degenerating factor (TDF). The characteristics of the TDF were as follows: 1) The molecular weight of the TDF was estimated to be 30k by SDS-PAGE. 2) It may be basic and glycosylated. 3) Its activity was inhibited by fibronectin and, vice versa, by binding TDF molecule with fibronectin molecule. 4) Its activity was enhanced by interferons. It is possible that the TDF is an important substance concerning the interaction between tumor cells and interstitial cells.
发现了一种新的人成纤维细胞生成因子，它在体外可使人类肿瘤细胞退化，并将其命名为肿瘤退化因子（TDF）。TDF的特性如下：1）通过SDS-PAGE估计TDF的分子量为30k。2）它可能是碱性且糖基化的。3）其活性被纤连蛋白抑制，反之，通过将TDF分子与纤连蛋白分子结合也可抑制纤连蛋白的活性。4）干扰素可增强其活性。TDF有可能是一种与肿瘤细胞和间质细胞之间相互作用有关的重要物质。
