眼部移植物抗宿主病中眼用环孢素的应用。
Ophthalmic cyclosporine use in ocular GVHD.
作者信息
Lelli Gary J, Musch David C, Gupta Anurag, Farjo Qais A, Nairus Theresa M, Mian Shahzad I
机构信息
Department of Ophthalmology and Visual Sciences, WK Kellogg Eye Center, University of Michigan Medical School, Ann Arbor, MI 48105, USA.
出版信息
Cornea. 2006 Jul;25(6):635-8. doi: 10.1097/01.ico.0000208818.47861.1d.
PURPOSE
To evaluate the safety and efficacy of topical ophthalmic cyclosporine in patients with dry eyes secondary to graft-versus-host disease (GVHD).
METHODS
Records of consecutive patients with ocular GVHD treated with topical cyclosporine were reviewed.
RESULTS
Thirty-two eyes of 16 patients were included with a mean follow-up of 90 days. Dry eye symptoms improved in 10 patients (62.5%), and corneal fluorescein staining improved in all eyes (P = 0.0039). Global physician impression was favorable in 12 patients (75%). Ocular burning or irritation was noted in 3 patients (19%), which improved with either continuation of cyclosporine at the current dosing regimen or reduction in dose and/or concentration of cyclosporine.
CONCLUSION
Ophthalmic cyclosporine seems to be safe and may be beneficial for patients with ocular GVHD, particularly those with more severe dry eyes.
目的
评估局部应用眼用环孢素治疗移植物抗宿主病（GVHD）继发干眼症患者的安全性和有效性。
方法
回顾性分析连续应用局部环孢素治疗眼部GVHD患者的病历。
结果
纳入16例患者的32只眼，平均随访90天。10例患者（62.5%）干眼症状改善，所有眼的角膜荧光素染色均有改善（P = 0.0039）。12例患者（75%）的整体医师评估结果良好。3例患者（19%）出现眼部烧灼感或刺激感，通过继续当前剂量方案使用环孢素或减少环孢素剂量和/或浓度，症状得到改善。
结论
眼用环孢素似乎安全，可能对眼部GVHD患者有益，尤其是那些干眼症较严重的患者。
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