Tobimatsu S, Tashima-Kurita S, Nakayama-Hiromatsu M, Kato M
Department of Clinical Neurophysiology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Electroencephalogr Clin Neurophysiol. 1991 Mar-Apr;80(2):89-93. doi: 10.1016/0168-5597(91)90145-n.
Pattern visual evoked potentials (VEPs) to transient and steady-state stimulation were recorded in 10 normal subjects at 4 levels of luminance (180, 57, 22 and 11 cd/m2). VEPs were also recorded in 5 patients with optic neuropathy at a fixed luminance (180 cd/m2). The relationship between P100 latency of transient VEPs (T-VEPs) and the phase of steady-state VEPs (S-VEPs) was analyzed. As luminance decreased in normal subjects, P100 latency was prolonged and the phase lag increased. A significant linear relationship between the P100 latency and phase was found. Patients showed both the prolonged P100 latency and the delayed phase. The simple linear regression line of the phase-P100 latency function of normal subjects closely matched the patients' values. These results suggest that changes in the phase may be equivalent to changes in the P100 latency. S-VEPs, therefore, may be clinically useful in assessing visual function.
在10名正常受试者中，于4种亮度水平（180、57、22和11坎德拉每平方米）记录了对瞬态和稳态刺激的图形视觉诱发电位（VEP）。还在5名视神经病变患者中于固定亮度（180坎德拉每平方米）记录了VEP。分析了瞬态VEP（T-VEP）的P100潜伏期与稳态VEP（S-VEP）的相位之间的关系。随着正常受试者亮度降低，P100潜伏期延长且相位滞后增加。发现P100潜伏期与相位之间存在显著的线性关系。患者同时表现出P100潜伏期延长和相位延迟。正常受试者相位-P100潜伏期函数的简单线性回归线与患者的值紧密匹配。这些结果表明，相位变化可能等同于P100潜伏期变化。因此，S-VEP在评估视觉功能方面可能具有临床应用价值。
