Tobimatsu S, Kurita-Tashima S, Nakayama-Hiromatsu M, Akazawa K, Kato M
Department of Clinical Neurophysiology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Electroencephalogr Clin Neurophysiol. 1993 Jan-Feb;88(1):12-9. doi: 10.1016/0168-5597(93)90023-i.
We recorded visual evoked potentials (VEPs) to checkerboard pattern-reversal stimulation in 109 normal subjects (51 males and 59 females; aged 19-84 years) in order to study the aging effect on the multiple channels of the visual system in humans. Transient VEPs to 3 check sizes (15', 30' and 50') were obtained by monocular stimulation. Two test conditions were employed: (1) a high luminance (180 cd/m2) and a low luminance (11 cd/m2) both with a fixed contrast (90%), and (2) a high contrast (85%) and a low contrast (10%) both at a fixed luminance (57 cd/m2). The major features of our results included: (1) the presence of a curvilinear relationship between P100 latency and age for all conditions, while the P100 amplitude did not show any such aging effect, (2) the age-latency function was similar between the two luminance conditions, while it was different between the two contrast conditions, and (3) the differential age effect on the P100 latency caused by changes in contrast depended on the check size. These results suggest that age-related changes in the human visual system are not uniform, but rather are different in the specific functional subdivisions. It is thus hypothesized that aging may differentially influence the separate channels of the human visual system.
我们对109名正常受试者（51名男性和59名女性；年龄19 - 84岁）进行了棋盘格模式翻转刺激下的视觉诱发电位（VEP）记录，以研究衰老对人类视觉系统多个通道的影响。通过单眼刺激获得了针对3种方格大小（15'、30'和50'）的瞬态VEP。采用了两种测试条件：（1）高亮度（180 cd/m²）和低亮度（11 cd/m²），两者对比度均固定为90%；（2）高对比度（85%）和低对比度（10%），两者亮度均固定为57 cd/m²。我们结果的主要特征包括：（1）在所有条件下，P100潜伏期与年龄之间存在曲线关系，而P100波幅未显示出任何此类衰老效应；（2）两种亮度条件下的年龄 - 潜伏期函数相似，而两种对比度条件下则不同；（3）对比度变化对P100潜伏期产生的不同年龄效应取决于方格大小。这些结果表明，人类视觉系统中与年龄相关的变化并非均匀一致，而是在特定功能细分中有所不同。因此推测，衰老可能对人类视觉系统的不同通道产生不同影响。
