Baumann Marcus, Baxendale Ian R, Ley Steven V, Smith Christoper D, Tranmer Geoffrey K
Innovative Technology Center (ACS), Department of Chemistry, University of Cambridge, Cambridge, UK, CB2 1EW.
Org Lett. 2006 Nov 9;8(23):5231-4. doi: 10.1021/ol061975c.
[Structure: see text] A multipurpose mesofluidic flow reactor capable of producing gram quantities of material has been developed as an automated synthesis platform for the rapid on-demand synthesis of key building blocks and small exploratory libraries. The reactor is configured to provide the maximum flexibility for screening of reaction parameters that incorporate on-chip mixing and columns of solid supported reagents to expedite the chemical syntheses.
[结构：见正文] 一种能够生产克级量材料的多功能微流体流动反应器已被开发出来，作为一种自动化合成平台，用于快速按需合成关键构建模块和小型探索性文库。该反应器的配置为筛选反应参数提供了最大的灵活性，这些参数包括片上混合和固体负载试剂柱，以加速化学合成。
