Department of Chemistry, Innovative Technnology Centre, University of Cambridge, Lensfield Road, Cambridge, UK CB2 1EW.
Org Biomol Chem. 2010 Apr 7;8(7):1588-95. doi: 10.1039/b924309g. Epub 2010 Feb 10.
The continuous flow synthesis of butane-2,3-diacetal protected derivatives has been achieved using commercially available flow chemistry microreactors in concert with solid supported reagents and scavengers to provide in-line purification systems. The BDA protected products are all obtained in superior yield to the corresponding batch processes.
使用市售的流动化学微反应器，结合固体支撑试剂和清除剂，实现了丁烷-2,3-二乙缩醛保护衍生物的连续流合成，从而提供了在线纯化系统。BDA 保护产物的收率均优于相应的分批工艺。
