Yoshimoto Akihiro, Kasahara Kazuo, Kawashima Atsuhiro
Department of Internal Medicine, Denentoshi Kosei Hospital, Yamato, and Department of Haematology-Oncology and Respiratory Medicine, Cellular Transplantation Biology, Kanazawa University Graduate School of Medical Science, Japan.
Eur J Cancer. 2006 Dec;42(18):3157-60. doi: 10.1016/j.ejca.2006.08.030. Epub 2006 Oct 31.
The aim of this study was to evaluate gastrointestinal metastases from primary lung cancer confirmed by autopsy. We identified and examined patients with a diagnosis of primary lung cancer over 33 years. We also reviewed patients with gastrointestinal metastases including the stomach, small bowel, and large bowel. This study comprised 470 patients with lung cancer. We detected 56 (11.9%) cases with gastrointestinal metastases. There were 12 (30%) cases with gastrointestinal metastases among 40 cases with large cell carcinoma. The histological type of large cell carcinoma led to a significantly higher rate of gastrointestinal metastases compared with that of non-large cell carcinoma (P=0.004, odds ratio 3.524). Life threatening gastrointestinal metastases occurred in 12 cases and five occurred in large cell carcinoma. Gastrointestinal metastases from primary lung cancer may occur in the clinical course and result in life threatening gastrointestinal metastases, particularly if patients have the histological type of large cell carcinoma.
本研究的目的是评估经尸检确诊的原发性肺癌的胃肠道转移情况。我们确定并检查了33年间诊断为原发性肺癌的患者。我们还回顾了有胃肠道转移的患者，包括胃、小肠和大肠。本研究包括470例肺癌患者。我们检测到56例（11.9%）有胃肠道转移。在40例大细胞癌患者中，有12例（30%）发生胃肠道转移。与非大细胞癌相比，大细胞癌的组织学类型导致胃肠道转移率显著更高（P = 0.004，优势比3.524）。12例发生危及生命的胃肠道转移，其中5例发生在大细胞癌患者中。原发性肺癌的胃肠道转移可能发生在临床病程中，并导致危及生命的胃肠道转移，特别是当患者为大细胞癌组织学类型时。
