Nguyen Khanh Toan, Linh Do Mai, Pham Thi Huong, Ngo Van Lam, Le Thi Hai Yen, Nguyen Thi Khanh Ha, Vo Thi Phuong Nhu, Oanh Truong Thi Kieu, Nga Le Thi Thu
Department of Medical Oncology 2 Nghe An Oncology Hospital Nghe An Vietnam.
Department of Oncology Hanoi Medical University Hanoi Vietnam.
Respirol Case Rep. 2025 May 4;13(5):e70200. doi: 10.1002/rcr2.70200. eCollection 2025 May.
Gastrointestinal metastasis from primary lung cancer is uncommon and metastasis to the appendix is particularly rare. It often presents with symptoms of acute appendicitis or remains asymptomatic, leading to incidental diagnosis. We report a rare case of lung cancer with metastasis to the appendix presenting as acute appendicitis. A 74-year-old male patient with a history of severe COPD was diagnosed with advanced-stage lung cancer and had been receiving targeted therapy for over a year. He subsequently developed acute appendicitis and underwent an appendectomy. Histopathological examination of the appendix revealed adenocarcinoma infiltrating the serosa of the appendix and immunohistochemistry staining was consistent with a primary adenocarcinoma lung cancer. Metastasis of lung cancer to the appendix is an extremely rare occurrence. This case highlights the diverse clinical manifestations in patients with metastatic lung cancer and underscores the importance of considering differential diagnoses for the aetiology of acute appendicitis, as it may be secondary metastasis.
原发性肺癌的胃肠道转移并不常见，转移至阑尾则尤为罕见。它通常表现为急性阑尾炎症状或无症状，导致偶然诊断。我们报告一例罕见的肺癌转移至阑尾并表现为急性阑尾炎的病例。一名有严重慢性阻塞性肺疾病病史的74岁男性患者被诊断为晚期肺癌，且已接受靶向治疗一年多。他随后发生急性阑尾炎并接受了阑尾切除术。阑尾的组织病理学检查显示腺癌浸润阑尾浆膜，免疫组化染色与原发性肺腺癌一致。肺癌转移至阑尾极为罕见。该病例突出了转移性肺癌患者的多样临床表现，并强调了考虑急性阑尾炎病因鉴别诊断的重要性，因为它可能是继发转移。
