Avery Thomas D, Macreadie Peter I, Greatrex Ben W, Robinson Tony V, Taylor Dennis K, Macreadie Ian G
Department of Chemistry, The University of Adelaide, 5005 SA, Australia.
Bioorg Med Chem. 2007 Jan 1;15(1):36-42. doi: 10.1016/j.bmc.2006.10.021. Epub 2006 Oct 31.
Broad antifungal structure-activity relationships governing epoxy-endoperoxides 2 and 3 and their parent endoperoxides 1 are reported. Their inhibitory activity against Candida albicans in conjunction with hemolytic activity and/or growth inhibition of cultured mammalian cells are reported. This information provided guidance for the further development of endoperoxide and epoxy-endoperoxides as topical antifungal agents.
