卡泊芬净对三种棘阿米巴滋养体和包囊的作用。
Effect of caspofungin on trophozoites and cysts of three species of Acanthamoeba.
作者信息
Bouyer Sabrina, Imbert Christine, Daniault Gyslaine, Cateau Estelle, Rodier Marie-Hélène
机构信息
Laboratoire de Parasitologie et Mycologie Médicale, CHU La Milètrie, BP 577, 86021 Poitiers Cedex, France.
出版信息
J Antimicrob Chemother. 2007 Jan;59(1):122-4. doi: 10.1093/jac/dkl451. Epub 2006 Oct 31.
OBJECTIVES
Amoebic keratitis is difficult to treat, without total efficacy in some patients because of cysts that are less susceptible than trophozoites to the usual treatments. We investigated here the in vitro effectiveness of caspofungin, a new antifungal, against three species of Acanthamoeba.
METHODS
Trophozoites and cysts of Acanthamoeba castellanii, Acanthamoeba culbertsoni and Acanthamoeba polyphaga were incubated with caspofungin at concentrations varying from 16 to 500 mg/L.
RESULTS
The trophozoites of the three tested species were susceptible in vitro to caspofungin at a concentration of 250 mg/L (206 microM). Furthermore, this drug was cysticidal at a concentration of 500 mg/L (412 microM) against A. castellanii and A. culbertsoni.
CONCLUSIONS
Caspofungin could represent, if in vivo studies confirm its efficacy, a new anti-Acanthamoeba compound.
目的
阿米巴角膜炎难以治疗，部分患者治疗效果不佳，原因是包囊对常用治疗的敏感性低于滋养体。我们在此研究了新型抗真菌药物卡泊芬净对三种棘阿米巴属物种的体外有效性。
方法
将卡氏棘阿米巴、库氏棘阿米巴和多噬棘阿米巴的滋养体和包囊与浓度为16至500mg/L的卡泊芬净一起孵育。
结果
三种受试物种的滋养体在体外对浓度为250mg/L（206μM）的卡泊芬净敏感。此外，该药物在浓度为500mg/L（412μM）时对卡氏棘阿米巴和库氏棘阿米巴具有杀包囊作用。
结论
如果体内研究证实其疗效，卡泊芬净可能成为一种新型抗棘阿米巴化合物。
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