Aguet M
Institute of Molecular Biology I, University of Zürich, Switzerland.
J Interferon Res. 1990 Dec;10(6):551-8. doi: 10.1089/jir.1990.10.551.
During the past few years, identification of cytokine receptors has become a major goal in cytokine research. A great deal has been learned from the plethora of receptor structures that have been elucidated recently. Although, evidently, the complexity of the cytokine network extends to the signaling pathways involved, some of these pathways have now become more accessible. The challenge in the coming years will be to fill the gap between the receptors and the gene regulatory events induced by the various cytokines. Another challenge lies in the potential use of cytokine receptors as targets for modulating cytokine action. Since the topic of interferon (IFN) receptors has been reviewed recently, this minireview will focus on the current knowledge on the IFN-gamma receptor in the context of recent advances on other cytokine receptors. Some new receptor models that may be of consequence for characterizing IFN receptors will be presented briefly.
在过去几年中，细胞因子受体的鉴定已成为细胞因子研究的主要目标。从最近阐明的大量受体结构中已经学到了很多东西。显然，细胞因子网络的复杂性延伸到所涉及的信号通路，尽管如此，其中一些通路现在已经更容易研究了。未来几年的挑战将是填补受体与各种细胞因子诱导的基因调控事件之间的空白。另一个挑战在于细胞因子受体作为调节细胞因子作用靶点的潜在用途。由于干扰素（IFN）受体的主题最近已有综述，本小型综述将在其他细胞因子受体最新进展的背景下，聚焦于当前对IFN-γ受体的认识。将简要介绍一些可能对IFN受体特征描述有重要意义的新受体模型。
